Development of Inhibitors to Target Glyoxylate and Methylcitrate Cycles Essential for Persistence of Mycobacterium Tuberculosis

Abstract

Mycobacterium tuberculosis is one of the most significant pathogen since its discovery in 1882. It causes one of the most deadly disease TB. It can occur in two stages in the body of the host cell, namely active stage and the persistent stage. Active stage in which the pathogen is active and damages the host system whereas in persistent stage, the pathogen is inactive and doesn’t cause any damage to the host system but remain dormant in the host system and becomes active whenever the immunity of the host is compromised. So, it becomes important to discover drugs which not only kills the pathogen in the active state but also in the persistent stage.