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Title: Computational Modeling of Cell Survival Using VHDL
Authors: Jain, Shruti
Naik, Pradeep K.
Bhooshan, Sunil V.
Keywords: Tumor Necrosis Factor-α
Epidermal Growth Factor
Issue Date: 2010
Publisher: Jaypee University of Information Technology, Solan, H.P.
Abstract: The model for cell survival has been implemented using Very High Speed Integrated Circuit Hardware Description Language (VHDL) (Xilinx Tool) taking three input signals: Tumor necrosis factor-α (TNF), Epidermal growth factor (EGF) and Insulin. Cell survival has been regulated by the interaction of five proteins viz P13K, TNFR1, EGFR, IRS and IKK in a network. In the absence of any one, in protein network leads to cell death. For the EGF input signal the proteins like MEK, ERK, AkT, Rac & JNK have been important for regulation of cell survival. Similarly for TNF and Insulin input signal proteins like NFκB, AkT, XIAP, JNK, MAP3K & MK2 and MEK, ERK, AkT, Rac, mTOR & JNK respectively have been important for regulation of cell survival.
Appears in Collections:Journal Articles

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