Please use this identifier to cite or link to this item: http://ir.juit.ac.in:8080/jspui/jspui/handle/123456789/7898
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dc.contributor.authorVR, Jyoti-
dc.contributor.authorKashyap, Himan-
dc.contributor.authorRout, Chittaranjan [Guided by]-
dc.date.accessioned2022-10-17T09:19:03Z-
dc.date.available2022-10-17T09:19:03Z-
dc.date.issued2014-
dc.identifier.urihttp://ir.juit.ac.in:8080/jspui/jspui/handle/123456789/7898-
dc.description.abstractTuberculosis, is a common, infectious disease caused by the bacteria Mycobacterium tuberculosis. TB kills around 1.7 million people every year despite the availability of effective chemotherapy for more than half a century. The remarkable capacity of this pathogen to escape the host immune system for decades and then to cause active tuberculosis disease, makes MTB a successful pathogen. Currently available anti-mycobacterial therapy has poor compliance due to requirement of prolonged treatment resulting in accelerated emergence of drug resistant strains. Bacterial efflux pump mechanism play a major role in development of drug resistance. While inhibitors can inactivate the efflux pumps and make the bacteria vulnerable to the drugs. So if inhibitors are taken along with drugs the disease could be effectively treated. So aim of this project is to design lead molecules for development of inhibitors against drug-resistant strains of TB and shortens the treatment period. A treatment that can eliminate TB in less time could interrupt the transmission of this deadly disease.en_US
dc.language.isoenen_US
dc.publisherJaypee University of Information Technology, Solan, H.P.en_US
dc.subjectLead moleculesen_US
dc.subjectEfflux pumpen_US
dc.subjectTuberculosisen_US
dc.titleDesign of Broad Specific Lead Molecules against Proteins Involved In Efflux Pump Mechanism in Mycobacterium Tuberculosisen_US
dc.typeProject Reporten_US
Appears in Collections:B.Tech. Project Reports



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