Please use this identifier to cite or link to this item: http://ir.juit.ac.in:8080/jspui/jspui/handle/123456789/9372
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dc.contributor.authorThakur, Raman-
dc.contributor.authorShankar, Jata-
dc.date.accessioned2023-01-24T05:10:55Z-
dc.date.available2023-01-24T05:10:55Z-
dc.date.issued2017-
dc.identifier.urihttp://ir.juit.ac.in:8080/jspui/jspui/handle/123456789/9372-
dc.description.abstractIn addition, bioengineering of T-cells has opened another approach to treat fungal infections in immunocompromised patients. The pattern recognition receptor such as soluble (Pentraxin-3) and cell bound receptors (Dectin-1) play crucial role in recognition and elimination of fungal pathogens [9]. Thus, the engineering of cell bound receptors on T-cell eliminate the need of MHC representation of antigens and fast removal of pathogens. Kumaresan et al. engineered cytotoxic T-cells to combat Aspergillus infections. They link the innate immune cell receptor (Dectin-1) with T-cells to redirect their specificity for Aspergillus fungus. A chimeric antigen receptor (CAR) was developed to express it on T-cell. Dectin-1, a receptor present on innate immune cells (e.g., macrophages, neutrophils and dendritic cells) was selected, which recognize β-glucan present on fungal cell wall. Kumaresean et al. use the sleeping beauty (SB) transposon/ transposase system to develop such cells. T-cells having these designated chimeric antigen receptors (D-CAR) have specificity for β- glucan and thus lead to damage of Aspergillus hyphae [en_US
dc.language.isoenen_US
dc.publisherJaypee University of Information Technology, Solan, H.P.en_US
dc.subjectMycologyen_US
dc.subjectVirologyen_US
dc.titleNew Treatment Regime for Aspergillus Mediated Infectionsen_US
dc.typeArticleen_US
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